How to Pick the Right HMO Supplements? - by Layer Origin

Layer Origin Product Guide - 2026

Product Key Benefits Form and Key Ingredients Who Is It For?
Akkermansia muciniphila Daily Probiotic with PureHMO Prebiotic
Akkermansia
  • Probiotic bacteria linked to weight management, healthy gut function, metabolism, blood sugar control, and strengthening of the gut barrier. 
  • HMO prebiotics support the innate immune system by blocking pathogens. 
  • Reduces inflammation by lowering the activity of pro-inflammatory cytokines.
  • Supports the production of healthy gut bacteria like Akkermansia muciniphila and others and boosts beneficial metabolites like butyrate.

Capsule

500 million AFUs of Akkermansia muciniphila (Live)

500 million CFUs of Akkermansia muciniphila (Pasteurized)

250 mg of 2’Fucosyllactose (2’FL) HMO prebiotics

750 mg of non-GMO resistant starch (maize) 

People with leaky gut or gut dysbiosis. People looking to support weight management, metabolism, or blood sugar control. People with IBS or digestive symptoms, like gas, bloating, or constipation. 

PureBifido™ Probiotics with 5 Strains of Bifidobacteria

  • Designed to Work with HMOs – Bifidobacteria thrive when supported by Human Milk Oligosaccharides (HMOs), such as 2’-FL, which can be used alongside this product to help feed and support bifidobacteria growth.*
  • Designed for Severely Low Bifidobacteria – Ideal for individuals who need targeted bifidobacteria seeding before dietary fibers or prebiotics alone can be effective.
  • 5 Key Bifidobacteria Strains – Contains Bifidobacterium infantis, B. breve, B. longum, B. bifidum, and B. adolescentis, species known for their foundational role in gut and immune health.

Capsule

30 Billion CFU of Bifidobacterium infantis, B. breve, B. longum, B. bifidum, and B. adolescentis,

Ideal for individuals who need targeted bifidobacteria seeding before dietary fibers or prebiotics alone can be effective.

Organic Apple Peel Powder

Apple peel

  • Antioxidants fight inflammation and support gut, heart, and joint health. 
  • Provides soluble and insoluble fiber.
  • Feeds healthy bacteria like Akkermansia, a probiotic linked to weight control, healthy guts, and blood sugar control. 

Powder

4.2 grams of AppleActiv apple peel powder per serving

People with constipation, dysbiosis, oxidative stress, or inflammation.

PureHMO® Human Milk Oligosaccharide (HMO 2'FL) Super Prebiotic Powder

  • Supports the growth of 200 billion healthy gut bacteria per serving.
  • Supports brain development, neuronal transmission, and cognitive function.
  • Clinically proven to reduce key symptoms of IBS such as gas, bloating, constipation, and other digestive discomforts.

Powder

Contains 2000 mg of Human Milk Oligosaccharides (HMO) per serving

People with leaky gut or gut dysbiosis. People with IBS or digestive symptoms, like gas, bloating, or constipation. 

PureHMO® Human Milk Oligosaccharide Super Prebiotic Capsules

  • Supports the growth of 180 billion healthy gut bacteria per serving,
  • Supports the innate immune system by blocking pathogens and reducing inflammation.
  •  Supports brain development, neuronal transmission, and cognitive function.
  • Clinically proven to reduce key symptoms of IBS such as gas, bloating, constipation, and other digestive discomforts.

Capsules

1,800 mg of Human Milk Oligosaccharides (HMO) 2’Fucosyllactose (2’FL)

People with leaky gut or gut dysbiosis. People with IBS or digestive symptoms, like gas, bloating, or constipation. 
SuperHMO® Human Milk Oligosaccharide Synbiotic: Prebiotic + Probiotic Combo
  • Support gut microbiome diversity. 
  • 10 probiotic strains work synergistically to help with immune function, digestive health, and mental health. 

Capsules

5 Kinds of HMO prebiotics and 10 probiotic strains totaling 40 billion CFUs 

People with IBS, constipation, or gut dysbiosis. 

PureHMO® IBS Support with IBS Defend Probiotic

IBS support

  • Improves IBS symptoms like constipation, gas, bloating, and diarrhea.
  • Combines Lactobacillus acidophilus probiotics with HMO prebiotic (2'-FL and LNnT) to restore beneficial microflora in the gut. 
  • Restores the gut lining, strengthens gut barriers, builds gut bacteria balance, and defends against bad bacteria and food intolerance. 

Powder

10 billion CFU of Lactobacillus acidophilus bacteria

1,000 mg of Lacto-n-neotetraose (LNnT), a type of HMO prebiotic

4,000 mg of  2’Fucosyllactose (2’FL), a type of HMO prebiotic. 

People with IBS.

The Constipiotic™ Prebiotic Fiber for Constipation with HMO, GOS, Inulin FOS

  • Relieves constipation and improves bowel regularity.
  • Feed different strains of probiotics in the gut (more than 50 strains) and help to increase the diversity of gut microbiota.
  • A greater gut microbiome diversity can digest food more efficiently, reducing bloating, inflammation, and constipation symptoms. 

Powder

1,000 mg of HMO (2’FL)

1,000 mg of GOS

2,000 mg of inulin (FOS)

People with IBS-C or constipation.

Simple Reds - Organic Red Polyphenols Fruit Powder
red fruits powder

  • Fights inflammation and oxidative stress.
  • Helps support the growth of healthy gut bacteria like Bifidobacteria and Akkermansia

Powder

Organic Strawberry Powder, Organic Cranberry Powder, Organic Apple Powder, Organic Blueberry Powder, and Organic Beet Root Powder

People who want an antioxidant-loaded powder to fight inflammation and oxidative stress.

People who want an energy boost. 

SuperHMO® Prebiotic for Kids - 5 HMOs

  • Mimics the composition of the true HMO profile found in breast milk.
  • Supports brain development, neuronal transmission, and cognitive function.
  • Support kids’ immune, brain, and digestive health. 

Powder 

540 mg of 2’FL 

150 mg of LNT

140 mg of LNnT

120 mg of 6’SL

50 mg of 3’SL 

Kids looking to improve digestive health, cognitive function, or immune health.

SuperHMO® Prebiotic Mix with 5 HMOs

SuperHMO

  • Promotes the growth of more than 100 strains of beneficial bacteria in the gut through cross-feeding reactions.
  • Supports brain development, neuronal transmission, and cognitive function.
  • Supports immune, brain, and digestive health. 

Powder 

2,250 mg of 2’FL

650 mg of LNT

600 mg of LNnT

500 mg of 6’SL

200 mg of 3’SL

Anyone looking to support digestive, immune, or cognitive health.