PureHMO® Prebiotic + Probiotic (Ships Dec. 14)

  • BEST PREBIOTIC + PROBIOTIC COMBO: most other probiotic supplements contain just a small amount (<50 mg) of prebiotics. By comparison, our formula contains a potent 1000 mg of the best prebiotic - Human Milk Oligosaccharide
  • MAXIMIZED SYNERGY: PureHMO® human milk oligosaccharide helps infants build a healthy digestive system from scratch. There is no better prebiotic than HMO to feed the probiotics and restore your gut
  • SHELF-STABLE: Max Synergy Prebiotic + Probiotic contains 100 BILLION CFU of live probiotics cultures at the time of production. The HMO encapsulates and provides a shelf-stable environment for probiotics
  • PROBIOTICS FOR WOMEN & MEN: Max Synergy Probiotic/Prebiotic is designed to restore the gut & immune system, relieve IBS & constipation, achieve healthy weight loss, and improve mental & overall health
  • CLINICALLY PROVEN PROBIOTICS STRAINS: Bifidobacterium bifidum UABb-10, Bifidobacterium lactis UABla-12, Bifidobacterium longum, Lactobacillus acidophilus UALa-01, Lactobacillus casei UALc-03, Lactobacillus gasseri UALg-05, Lactobacillus paracasei UALpc-04, Lactobacillus plantarum UALp-05, Lactobacillus reuteri, Lactobacillus rhamnosus

    Customer Reviews

    Based on 8 reviews
    Dmitry Varenik
    Not sure yet for certain...

    Been having better bowel movements and better formed stools, my mother says it's been helping her too, and she doesn't take it consistently because she doesn't like taking pills, but also suffers from similar digestive issues as me after catching H.Pylori in the past like myself, also happy that this product passed the milk test which shows the probiotics are alive, as you can see in the picture, I had a strong feeling it would pass, since "Layer Origins" is affiliated with Cornell University, I hope you guys keep making more research and find a solution for people who have IBS and dysbiosis, thank you and have a great day...

    Tammy Trew
    Outstanding thus far!!

    Not only have I used this but I also have passed this on to some friends. One in particular now has found this to help her tremendously to the point of avoiding a trip to the ER after having a serious digestive disturbance. I also have used the powder and it's great! I love that this is a pre/probiotic formula! Excited to share this with my sister, and the science being discovered as well!

    very good

    The best pre/pro on the planet!.Verified strains and works, no more bloating.

    Susan Yatsky
    nice product

    As an acupuncturist, I was impressed with the Prebiotic Probiotic product. The science behind the product is right on target and the HMO prebiotic is very important and appreciated! I've searched high and low for a product that meets my standards. I will definitely purchase again. Thanks!

    Tiffinay James
    Absolutely a great company

    It was easy to navigate the website. Ordering was easy and I got my products in a very timely manner. I absolutely love their products!

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    The sad reality is that most probiotic supplements contain only a very small amount (<50mg) of prebiotics. 

    By comparison, our formula has a potent 1000mg of the best prebiotic available today: Human Milk Oligosaccharide (HMO). 

    PureHMO® Prebiotic + Probiotic is designed to:

    • restore the gut and immune system
    • relieve symptoms of IBS such as constipations gas, pain, & bloating
    • promote healthy weight loss
    • improve mental & overall health




    PureHMO® normalizes gut movements & blocks inflammations

    PureHMO® inhibits adhesion of pathogens & viruses to the gut lining

    Feed beneficial bacteria in the gut, like bifidobacteria to maintain a healthy gut microbiome


    Scientists have identified over 200 different complex sugar molecules, known as human milk oligosaccharides (HMOs), in humans. In other mammals there are only about 50. After lactose and fats, these sugars are the third most abundant component in human milk. But humans are missing the enzymes needed to process those sugars so they pass through the stomach and into the small intestine, undigested.

    The sugars nourish a very important subspecies of bacteria called Bifidobacterium longum infantis, which then raises the acidity of the substrate as it feeds off of the HMOs.

    Inside the gut, this makes the environment more hostile to pathogens like E.Coli. The bacteria B. infantis also boosts production of proteins that close gaps between gut cells to keep microbes out of the bloodstream and increases anti-inflammatory molecules that boost the immune system. To achieve those beneficial results, B. infantis has to feed on HMOs. 


    2'-Fucosyllactose is one type of Human Milk Oligosaccharide. There are more than 200 different types of HMOs in all with 2'-FL as the most abundant variety accounting for about 30% of all HMOs. It is an oligosaccharide - specifically it is fucosylated, neutral trisaccharide composed of L-fucose, D-galactose, and D-glucose units. It can be biosynthesized at scale using E. Coli. 

    As with other oligosaccharides, a main characteristic of 2'-Fucosyllactose is its ability to protect against infectious disease. It's best known for preventing epithelial level adhesions of toxins and pathogens. The 2'-FL stimulates the growth of bifidobacteria and receptor analogons which leads to toxic and pathogenic protection. 2'-FL is known to protect against Campylobacter jejuni, Salmonella enterica serotype Typhimurium, Helicobacter pylori, and others.

    Research into the various health benefits of HMOs has accelerated as more HMO varieties become commercially available at scale. We're ranking benefits based on data and findings in research publications on HMOs. There is extensive researching demonstrating that 2'FL and LNnT provide benefits for gut health. There is some evidence, but not quite as strong, that both 2'FL and LNnT provide benefits for immune health. Brain health is boosted by 2'FL, 3'SL, and 6'SL according to some of the available research.

    Be sure to choose the right human milk oligosaccharide supplement for you, whether it is a 2'-FL supplement, or one that is a combination — a 2'-Fucosyllactose, Lacto-N-neotetraose supplement. 


    Both human milk oligosaccharides (HMOs) and prebiotic oligosaccharides (PBOs) belong to the large class of carbohydrates, but they have com­pletely different structures.

    Human Milk Oligosaccharides have been growing in popularity in human nutrition since 2015. HMO is naturally found in breast milk and serves as nature's preferred prebiotic. They are produced in the lactating mammary glands

    HMO is a special prebiotic that's quite different from GOS, FOS, and XOS because of where it comes from.

    Human Milk Oligosaccharide (HMO) consists of complex sugar molecules. Unlike GOS, FOS, and even XOS, which can cause some of same problems people take them to avoid (gas, bloating, IBS sypmtoms), HMO does not have that effect.

    When considering the difference be¬tween GOS/FOS and HMOs, two major aspects have to be considered:

    (A) The monosaccharide composition

    (B) The linkage between them. The linkage is very important because specific functions including defense mechanisms, immune functions, or anti-inflammatory effects strongly de-pend on those linkages.


    Research has shown that 2'-FL supports the development of a healthy gut and immune system, protection against allergic diseases and plays a role in the development of normal brain functions and cognition in early life and beyond.

    2'FL has been shown to be vital for digestive health by promoting growth of beneficial bacteria, inhibit adhesion of pathogens, quenching inflammation and normalizing gut movements.

    *HMOs primarily increase a type of intestinal microbiota called Bifidobacteria. 

    In a study of health adults charting Bifidobacteria fold change over the baseline amount, HMOs were shown to beneficially modulate the intrinsic intestinal microbiota. 

    The two HMOs tested were 2'FL and LNnT. They were compared to a placebo. 

    Want to learn more about the clinical trials? Contact us for additional information. 

    *Healthy Adults (n=100), 14 days intervention


    PureHMO Prebiotic Benefits
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