PureHMO® Human Milk Oligosaccharide Prebiotic Powder

  • Prebiotic Fiber Based on Mother's Milk: Human milk oligosaccharides (HMO) are prebiotics initially found in mother's milk. HMO helps build a healthy gut and immune system for human from scratch.  
  • Produced with Highest Purity: PureHMO® powder is 98% 2'-Fucosyllactose (2'-FL), the most abundant HMO in human milk, produced by fermentation technology, It is not isolated from human milk. 
  • Promote Digestive Health: HMO prebiotic powder promotes the growth of probiotics like Lactobacillus, Bifidobacterium, and supports a healthy gut environment.
  • Support Immune Functions: HMOs are more effective than non-human prebiotics in stimulating the innate immune system, inhibiting pathogens and viruses, and blocking inflammation.
  • Improve Cognitive Function: Unlike other prebiotic and probiotic products for adults, HMO metabolites by the probiotics in your gut can promote brain development, neuronal transmission, and cognition.

      Customer Reviews

      Based on 17 reviews
      Pax Frias-donaghey
      Prebiotic on steroids!

      This simple molecule has set the tone for my gut health. It's the real deal. Watch out at first and heed the recommendation to take less than a full dose, but once you build up the tolerance and the biome in your gut--you'll know why I'm so enthusiastic. Thanks for sending it up to Canada.

      Cathy Theiss
      Pure HMO Prebiotic Powder

      This stuff is super easy to take and all my kids are able to easy take it. Taste is perfect (no taste really haha).

      Janice Lutke

      I am impressed with this product

      Coralie Phanord
      It seems to work!

      I feel full longer

      Anthony Bronzo
      Great product, gets results

      Started taking this and started getting better sleep and my slow digestion improved dramatically.

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      PureHMO® normalizes gut movements & blocks inflammations

      PureHMO® inhibits adhesion of pathogens & viruses to the gut lining

      Feed beneficial bacteria in the gut, like bifidobacteria to maintain a healthy gut microbiome


      Trish Whetstone with PureHMO Prebiot

      Trish Whetstone (@feelgoodgutgirl)

      Certified Health Coach +
      Master Certified Nutrition & Wellness Coach

      Trish Whetstone certification badges

      "I've been taking HMO prebiotics for over a month now, and I immediately noticed a difference in these products compared to other prebiotics ... my bowel movements have become more regular and comfortable (I am prone to constipation). I am also lactose intolerant and have had no reaction to the HMO in this."


      Scientists have identified over 200 different complex sugar molecules, known as human milk oligosaccharides (HMOs), in humans. In other mammals there are only about 50. After lactose and fats, these sugars are the third most abundant component in human milk. But humans are missing the enzymes needed to process those sugars so they pass through the stomach and into the small intestine, undigested.

      The sugars nourish a very important subspecies of bacteria called Bifidobacterium longum infantis, which then raises the acidity of the substrate as it feeds off of the HMOs.

      Inside the gut, this makes the environment more hostile to pathogens like E.Coli. The bacteria B. infantis also boosts production of proteins that close gaps between gut cells to keep microbes out of the bloodstream and increases anti-inflammatory molecules that boost the immune system. To achieve those beneficial results, B. infantis has to feed on HMOs. 


      2'-Fucosyllactose is one type of Human Milk Oligosaccharide. There are more than 200 different types of HMOs in all with 2'-FL as the most abundant variety accounting for about 30% of all HMOs. It is an oligosaccharide - specifically it is fucosylated, neutral trisaccharide composed of L-fucose, D-galactose, and D-glucose units. It can be biosynthesized at scale using E. Coli. 

      As with other oligosaccharides, a main characteristic of 2'-Fucosyllactose is its ability to protect against infectious disease. It's best known for preventing epithelial level adhesions of toxins and pathogens. The 2'-FL stimulates the growth of bifidobacteria and receptor analogons which leads to toxic and pathogenic protection. 2'-FL is known to protect against Campylobacter jejuni, Salmonella enterica serotype Typhimurium, Helicobacter pylori, and others.

      Types of Human Milk Oligosaccharides

      Research into the various health benefits of HMOs has accelerated as more HMO varieties become commercially available at scale. We're ranking benefits based on data and findings in research publications on HMOs. There is extensive researching demonstrating that 2'FL and LNnT provide benefits for gut health. There is some evidence, but not quite as strong, that both 2'FL and LNnT provide benefits for immune health. Brain health is boosted by 2'FL, 3'SL, and 6'SL according to some of the available research.

      Be sure to choose the right human milk oligosaccharide supplement for you, whether it is a 2'-FL supplement, or one that is a combination — a 2'-Fucosyllactose, Lacto-N-neotetraose supplement. 


      Both human milk oligosaccharides (HMOs) and prebiotic oligosaccharides (PBOs) belong to the large class of carbohydrates, but they have com­pletely different structures.

      Human Milk Oligosaccharides have been growing in popularity in human nutrition since 2015. HMO is naturally found in breast milk and serves as nature's preferred prebiotic. They are produced in the lactating mammary glands

      HMO is a special prebiotic that's quite different from GOS, FOS, and XOS because of where it comes from.

      Human Milk Oligosaccharide (HMO) consists of complex sugar molecules. Unlike GOS, FOS, and even XOS, which can cause some of same problems people take them to avoid (gas, bloating, IBS sypmtoms), HMO does not have that effect.

      When considering the difference be¬tween GOS/FOS and HMOs, two major aspects have to be considered:

      (A) The monosaccharide composition

      (B) The linkage between them. The linkage is very important because specific functions including defense mechanisms, immune functions, or anti-inflammatory effects strongly de-pend on those linkages.


      Research has shown that 2'-FL supports the development of a healthy gut and immune system, protection against allergic diseases and plays a role in the development of normal brain functions and cognition in early life and beyond.

      2'FL has been shown to be vital for digestive health by promoting growth of beneficial bacteria, inhibit adhesion of pathogens, quenching inflammation and normalizing gut movements.

      *HMOs primarily increase a type of intestinal microbiota called Bifidobacteria. 

      In a study of health adults charting Bifidobacteria fold change over the baseline amount, HMOs were shown to beneficially modulate the intrinsic intestinal microbiota. 

      The two HMOs tested were 2'FL and LNnT. They were compared to a placebo. 

      Want to learn more about the clinical trials? Contact us for additional information. 

      *Healthy Adults (n=100), 14 days intervention

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