PureHMO® Human Milk Oligosaccharide Prebiotic Powder

  • Prebiotic Fiber Based on Mother's Milk: Human milk oligosaccharides (HMO) are prebiotics initially found in mother's milk. HMO helps build a healthy gut and immune system for human from scratch.  
  • Produced with Highest Purity: PureHMO® powder is 98% 2'-Fucosyllactose (2'-FL), the most abundant HMO in human milk, produced by fermentation technology, It is not isolated from human milk. 
  • Promote Digestive Health: HMO prebiotic powder promotes the growth of probiotics like Lactobacillus, Bifidobacterium, and supports a healthy gut environment.
  • Support Immune Functions: HMOs are more effective than non-human prebiotics in stimulating the innate immune system, inhibiting pathogens and viruses, and blocking inflammation.
  • Improve Cognitive Function: Unlike other prebiotic and probiotic products for adults, HMO metabolites by the probiotics in your gut can promote brain development, neuronal transmission, and cognition.

      Customer Reviews

      Based on 12 reviews
      C. Norris
      Great Product

      Very easy to take. Dissolves quickly and is flavorless. Fast delivery.

      Steven Cunningham
      Making a difference!

      Both myself and my wife have started using PureHMO. Whilst this has been in conjunction with other dietary changes , we have both noticed an rapid decrease in digestive issues . Would recommend to anyone with gut issues

      Richard Rosenbloom
      Some results

      I have noticed a reduction in lower gut discomfort but not enough yet for more than 3 stars.
      I’m a research physician who is on the advisory board of a Microbiome research company and have used pre and ptobiotics clinically in a population of brain injured children. I know what to look for.

      Geraldine Lewis-Wireman
      Saved my life

      I've tried everything from Dr prescribed meds to diet, supplements, etc for over a year. I had to quit my job last year due to ibs-c and have struggled for a solution. I took a chance on layer origin nutrition and I'm so glad I did! I felt better than I have in a year within a few days. And after over a month I can still say it's a great product I'll continue to use!

      Dan Berman
      Better health results

      Results so far are less bloating and less gas
      Overall desirable outcome

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      PureHMO® normalizes gut movements & blocks inflammations

      PureHMO® inhibits adhesion of pathogens & viruses to the gut lining

      Feed beneficial bacteria in the gut, like bifidobacteria to maintain a healthy gut microbiome


      Scientists have identified over 200 different complex sugar molecules, known as human milk oligosaccharides (HMOs), in humans. In other mammals there are only about 50. After lactose and fats, these sugars are the third most abundant component in human milk. But humans are missing the enzymes needed to process those sugars so they pass through the stomach and into the small intestine, undigested.

      The sugars nourish a very important subspecies of bacteria called Bifidobacterium longum infantis, which then raises the acidity of the substrate as it feeds off of the HMOs.

      Inside the gut, this makes the environment more hostile to pathogens like E.Coli. The bacteria B. infantis also boosts production of proteins that close gaps between gut cells to keep microbes out of the bloodstream and increases anti-inflammatory molecules that boost the immune system. To achieve those beneficial results, B. infantis has to feed on HMOs. 


      2'-Fucosyllactose is one type of Human Milk Oligosaccharide. There are more than 200 different types of HMOs in all with 2'-FL as the most abundant variety accounting for about 30% of all HMOs. It is an oligosaccharide - specifically it is fucosylated, neutral trisaccharide composed of L-fucose, D-galactose, and D-glucose units. It can be biosynthesized at scale using E. Coli. 

      As with other oligosaccharides, a main characteristic of 2'-Fucosyllactose is its ability to protect against infectious disease. It's best known for preventing epithelial level adhesions of toxins and pathogens. The 2'-FL stimulates the growth of bifidobacteria and receptor analogons which leads to toxic and pathogenic protection. 2'-FL is known to protect against Campylobacter jejuni, Salmonella enterica serotype Typhimurium, Helicobacter pylori, and others.

      Research into the various health benefits of HMOs has accelerated as more HMO varieties become commercially available at scale. We're ranking benefits based on data and findings in research publications on HMOs. There is extensive researching demonstrating that 2'FL and LNnT provide benefits for gut health. There is some evidence, but not quite as strong, that both 2'FL and LNnT provide benefits for immune health. Brain health is boosted by 2'FL, 3'SL, and 6'SL according to some of the available research.

      Be sure to choose the right human milk oligosaccharide supplement for you, whether it is a 2'-FL supplement, or one that is a combination — a 2'-Fucosyllactose, Lacto-N-neotetraose supplement. 


      Both human milk oligosaccharides (HMOs) and prebiotic oligosaccharides (PBOs) belong to the large class of carbohydrates, but they have com­pletely different structures.

      Human Milk Oligosaccharides have been growing in popularity in human nutrition since 2015. HMO is naturally found in breast milk and serves as nature's preferred prebiotic. They are produced in the lactating mammary glands

      HMO is a special prebiotic that's quite different from GOS, FOS, and XOS because of where it comes from.

      Human Milk Oligosaccharide (HMO) consists of complex sugar molecules. Unlike GOS, FOS, and even XOS, which can cause some of same problems people take them to avoid (gas, bloating, IBS sypmtoms), HMO does not have that effect.

      When considering the difference be¬tween GOS/FOS and HMOs, two major aspects have to be considered:

      (A) The monosaccharide composition

      (B) The linkage between them. The linkage is very important because specific functions including defense mechanisms, immune functions, or anti-inflammatory effects strongly de-pend on those linkages.


      Research has shown that 2'-FL supports the development of a healthy gut and immune system, protection against allergic diseases and plays a role in the development of normal brain functions and cognition in early life and beyond.

      2'FL has been shown to be vital for digestive health by promoting growth of beneficial bacteria, inhibit adhesion of pathogens, quenching inflammation and normalizing gut movements.

      *HMOs primarily increase a type of intestinal microbiota called Bifidobacteria. 

      In a study of health adults charting Bifidobacteria fold change over the baseline amount, HMOs were shown to beneficially modulate the intrinsic intestinal microbiota. 

      The two HMOs tested were 2'FL and LNnT. They were compared to a placebo. 

      Want to learn more about the clinical trials? Contact us for additional information. 

      *Healthy Adults (n=100), 14 days intervention

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