How do prebiotic supplements interact with medications?

There is limited research on the potential interactions between prebiotic supplements and medications. However, some studies suggest that prebiotics may affect the absorption, metabolism, or efficacy of certain medications.

Here are some examples of potential interactions between prebiotics and medications:

• Immunosuppressants: Prebiotics may interact with immunosuppressant medications, such as tacrolimus and cyclosporine, by affecting their absorption and metabolism.
• Chemotherapy drugs: Prebiotics may interfere with the absorption and metabolism of chemotherapy drugs, potentially reducing their effectiveness.
• Diabetes medications: Prebiotics may interact with diabetes medications, such as metformin, by affecting their absorption and metabolism. One study found that taking prebiotics alongside metformin may reduce blood glucose levels more effectively than metformin alone.
• Heart medications: Prebiotics may interact with certain heart medications, such as digoxin, by affecting their absorption and metabolism.

References:

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Jang KH, Lee JE, Kim JY, et al. Effects of prebiotics on the pharmacokinetics of orally administered tacrolimus in rats. Eur J Drug Metab Pharmacokinet. 2015;40(3):305-311.

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