Discover Layer Origin’s Brain Performance™ supplement, its unique HMO formula, and how it compares to the top 5 brain health supplements on the market.
Introduction
In today’s society, our brains are being put through their paces, and, in many cases, working overtime. Whether it’s juggling deadlines at work, studying for exams, or simply staying cognitively sharp as we age, cognitive performance has never been more important. It’s no surprise that brain health and performance supplements, often referred to as nootropics, have risen in popularity.
With so many products on the market, how do you know which is the best, which ones actually deliver results, and which is safest? At Layer Origin Nutrition, we’ve developed our own supplement to support your memory, focus, and clarity using a combination of powerful ingredients.
So, join us as we explore what makes Brain Performance™ different, break down its active ingredients, explain how it works, and how it compares to 5 of the most popular supplements on the market today.
What is Brain Performance™?
Brain Performance™ is a premium supplement that has been formulated to support cognitive function via both the gut-brain axis and direct neuronal pathways. Unlike nootropics that tend to rely on long lists of trendy ingredients, think Ginkgo biloba, Ashwagandha, and so on, Brain Performance™ combines a carefully selected set of compounds backed by scientific evidence.
The Brain Performance™ formula targets key aspects of cognitive health, including:
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Memory and learning: supporting the brain’s natural ability to process and retain information
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Focus and clarity: keeping mental fatigue at bay and enhancing concentration
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Long-term support: helping defend against age-related cognitive decline
What sets Brain Performance™ apart is its inclusion of human milk oligosaccharides (HMOs), which feed beneficial gut microbes that produce important neuroactive compounds as well as delivering sialic acid, an important compound to support brain and nerve health.
Key active ingredients in Brain Performance™
When it comes to the benefits of Brain Performance™, it’s important to understand the key ingredients and how they can support your cognition. The unique thing about Brain Performance™ is that it is the first formula to combine sialylated HMOs with phosphatidylserine and key B vitamins. Let’s take a closer look at what they are.
1. Human milk oligosaccharides
HMOs are important prebiotic fibers that are naturally present in human breast milk. They’re known for modulating the infant gut microbiome and supporting early immune system and brain development [1]. However, they also have an important role in the gut-brain axis, the communication network between the digestive system and the brain.
Brain Performance contains 2 types of HMO:
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Fucosylated HMO: The supplement contains 2’-fucosyllactose, the most abundant HMO, accounting for almost 30% of HMOs in breast milk [2]. As well as its many benefits of promoting the diversity of the gut microbiome, supporting immunity, and enhancing the abundance of Bifidobacteria, 2’-FL has been shown in animal studies to contribute to cognitive development through its gut modulation properties and by increasing the production of important neurotransmitters, like serotonin [3].
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Sialylated HMOs: The inclusion of 3’sialyllactose (3’SL) and 6’-sialyllactose (6’SL) also helps to nourish the gut microbiota, but they also deliver sialic acid, which is important for the formation of gangliosides in the brain.
2. Phosphatidylserine
A type of phospholipid which is naturally found in the brain’s cell membranes and protects the inside of the cell from the exterior environment. It’s necessary for healthy nerve cell membranes and myelin, the fatty sheath that protects nerve fibers [4]. Clinical trial data have shown that food supplements containing phosphatidylserine can improve cognitive functioning and even help to facilitate improvements in your short-term memory [5].
3. B vitamin complex
The B vitamin complex is a group of B vitamins that play important roles in several of the body’s functions, including heart and cell health. Research also shows that supplementation with B vitamins is associated with slowing cognitive decline, and an increased intake of folate can reduce the risk of dementia [6]. Read more about the link between the gut microbiota and B vitamins in our guide: “What Vitamins Are Produced in the Gut?”
How does Brain Performance™ work?
Brain Performance™ works in several ways by addressing multiple pathways involved in cognitive performance and brain protection. For example, the inclusion of the sialylated HMOs, 3’-SL and 6’-SL, increases gangliosides in the brain and the sialic acid they deliver acts as signalling molecules to the gangliosides [7]. Without normal and optimal ganglioside production and function, we can be susceptible to neurodegenerative conditions, but they are also important for neurotransmission and are a critical part of learning and memory [8].
Therefore, the inclusion of these HMOs helps to ensure the efficient delivery of sialic acid to facilitate the normal and increased function of gangliosides. However, the prebiotic effects of the HMOs also promote the growth of beneficial gut microbes that are known to produce neuroactive compounds that support your ability to focus, promote a sense of calmness, and balance your mood. One example is the production of GABA, an important neurotransmitter which, in reduced levels, can contribute to the development of anxiety disorders [9]. By increasing the production of GABA, there is a potential that, through the modulation of the gut-brain-axis signalling, Bifidobacteria could positively impact the brain, specifically mood.
Phosphatidylserine is a critical structural component of cell membranes, especially those located in the brain. It has crucial roles in cell signalling and is essential for cognitive functions, including:
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Learning
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Memory
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Attention
In one study investigating the effects of phosphatidylserine in adults with mild cognitive impairment, the results demonstrated that after a year, compared to placebo, it:
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improved short-term memory
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improved arithmetic testing and similarity test results
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increased the production of omega-3s and neurotransmitters [10]
So, phosphatidylserine can help improve learning, memory, and recall, while the inclusion of essential B vitamins helps to enhance neurotransmitter synthesis, increase mental energy, and promote healthy homocysteine metabolism for long-term brain health.
Brain Performance™ vs the top 5 brain supplements

Brain Performance™ by Layer Origin
When compared to the competition, Brain Performance™ stands out for several reasons. They are:
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Unique use of HMOs: None of the other nootropics available on the market target the gut-brain axis in the same way, giving Brain Performance™ a unique advantage.
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Evidence-based ingredients: All of the ingredients included in Brain Performance™ have been scientifically researched for their proven cognitive and brain health benefits.
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Balanced and targeted formula: Contains a select few ingredients that work synergistically.
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Cost-effective: No need to spend $100s on looking after your cognitive wellbeing, Brain Performance™ is a cost-effective supplement suitable for all.
Summary: Take charge of your Brain Performance™ today
Your brain is one of your most valuable assets, and investing in it now will pay dividends for years to come. With its unique combination of HMOs, phosphatidylserine, and essential B vitamins, Brain Performance™ offers a smarter, science-backed approach to cognitive health.
Don’t settle for generic nootropics that can cost the earth with little scientific evidence to prove that they are effective. Instead, choose a product that’s grounded in research and crafted with precision.
Unlock your potential with Brain Performance™ today!
Written by: Leanne Edermaniger, M.Sc. Leanne is a professional science writer who specializes in human health and enjoys writing about all things related to the gut microbiome.