How do prebiotics work, and what are some common sources of prebiotic fiber?

June 29, 2023 3 min read

How do prebiotics work, and what are some common sources of prebiotic fiber?

Prebiotics are a type of dietary fiber that are essential for the growth and activity of beneficial gut bacteria, known as probiotics. While probiotics are living microorganisms that help support a healthy gut microbiome, prebiotics are non-digestible carbohydrates that nourish these bacteria and promote their growth and activity in the gut. In this way, prebiotics serve as a fuel source for the beneficial bacteria in the gut, allowing them to thrive and perform their vital functions in the body.

The gut microbiome is a complex ecosystem of microorganisms that inhabit the digestive tract, including bacteria, viruses, fungi, and other microorganisms. This ecosystem plays a crucial role in maintaining overall health and wellbeing, including digestion, immune function, metabolism, and mental health. However, the gut microbiome can be disrupted by a variety of factors, including diet, medications, stress, and illness, which can lead to a variety of health problems.

Prebiotics work by selectively stimulating the growth and activity of beneficial gut bacteria, while inhibiting the growth of harmful bacteria. Unlike other dietary fibers that are broken down and absorbed in the small intestine, prebiotic fibers pass through the small intestine intact and are fermented by bacteria in the large intestine. During this fermentation process, the beneficial bacteria break down the prebiotic fibers into short-chain fatty acids (SCFAs), which are then used as a fuel source by the cells lining the gut.

SCFAs are important for maintaining gut health, as they help to nourish the gut lining, reduce inflammation, and regulate immune function. Additionally, SCFAs have been shown to have a variety of health benefits throughout the body, including improving insulin sensitivity, reducing inflammation, and promoting satiety and weight loss.

Some common sources of prebiotic fiber include:

  1. Inulin: A type of soluble fiber found in many plant-based foods, including chicory root, onions, garlic, asparagus, bananas, and wheat.
  2. Fructooligosaccharides (FOS): A type of soluble fiber found in many fruits and vegetables, including bananas, onions, garlic, and asparagus.
  3. Resistant starch: A type of carbohydrate that resists digestion in the small intestine and is fermented in the large intestine by gut bacteria. Sources of resistant starch include cooked and cooled potatoes, beans, lentils, and green bananas.
  4. Beta-glucans: A type of soluble fiber found in oats, barley, and mushrooms.
  5. Galactooligosaccharides (GOS): found some legumes, including lentils and chickpeas.
  6. Human milk oligosaccharides: A type of soluble fiber found in human milk, but is also available commercially through a precision fermentation process.

While prebiotics offer many potential health benefits, it is important to note that not all fibers are prebiotics. Some fibers, such as psyllium and wheat bran, do not have prebiotic properties and do not nourish the gut microbiome. Therefore, it is important to consume a variety of prebiotic fibers from a variety of sources to support a healthy gut microbiome.

In conclusion, prebiotics play a crucial role in maintaining a healthy gut microbiome, and by extension, overall health and wellbeing. By selectively stimulating the growth and activity of beneficial gut bacteria, prebiotics promote gut health, reduce inflammation, and regulate immune function. Incorporating prebiotic-rich foods into the diet, such as onions, garlic, asparagus, bananas, and legumes, can help support a healthy gut microbiome and improve overall health.

References:

  1. Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. The Journal of nutrition. 1995 Jun;125(6):1401-12.
  2. Roberfroid MB. Prebiotics and probiotics: are they functional foods?. The American journal of clinical nutrition. 2000 Jun 1;71(6):1682S-7S.
  3. Brownawell AM, Caers W, Gibson GR, Kendall CW, Lewis KD, Ringel Y, Slavin JL. Prebiotics and the health benefits of fiber: current regulatory status, future research, and goals. The Journal of nutrition. 2012 May 1;142(5):962-74.
  4. Slavin J. Fiber and prebiotics: mechanisms and health benefits. Nutrients. 2013 Apr;5(4):1417-35.
  5. Holscher HD. Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut microbes. 2017 Mar 4;8(2):172-84.
  6. Bindels LB, Delzenne NM, Cani PD, Walter J. Towards a more comprehensive concept for prebiotics. Nature Reviews Gastroenterology & Hepatology. 2015 Sep;12(5):303-10.
  7. Rastall RA, Gibson GR, Gill HS, Guarner F, Klaenhammer TR, Pot B, Reid G, Rowland IR, Sanders ME. Modulation of the microbial ecology of the human colon by probiotics, prebiotics and synbiotics to enhance human health: An overview of enabling science and potential applications. FEMS microbiology ecology. 2005 Jan 1;52(2):145-52.


Leave a comment


Also in GUT HEALTH KNOWLEDGE CENTER

How The Gut Microbiome Modulates Healthy Aging - Cover Image
How The Gut Microbiome Modulates Healthy Aging?

July 20, 2024 17 min read

Aging is inevitable, but why do some people age better than others? The answer lies in a mix of genetic, environmental, and lifestyle factors. Another key player is the gut microbiome, which might hold the key to longevity and health. Using a review by Ghosh et al. (2022), we explore the role of the gut microbiome in healthy aging, chronic disease development, and strategies to help you age healthily. 

Read More
The Human Milk Oligosaccharide - 2'-Fucosyllactose (2'-FL) Prevents Intestinal Inflammation Cover Image
The Human Milk Oligosaccharide - 2'-Fucosyllactose (2'-FL) Prevents Intestinal Inflammation, Study Finds

July 12, 2024 7 min read

Human milk oligosaccharides (HMOs), particularly the glycan known as 2’-Fucosyllactose (2’-FL), have been a cornerstone in neonatal nutrition, offering the first sweet taste and vital energy while establishing a thriving gut microbiome. Recent studies have expanded the understanding of these substances, with research showing 2’-FL's pivotal role in not only fostering beneficial gut bacteria but also in potentially mitigating adult conditions such as colitis. The Schalich et al. (2024) study further explores this by investigating 2’-FL's ability to modulate gut microbial metabolism, suggesting a promising future for HMOs in adult disease prevention and therapy, particularly for inflammatory bowel diseases like colitis.
Read More
How Akkermansia Survives and Thrives in the Gut?
How Akkermansia Survives and Thrives in the Gut?

June 27, 2024 6 min read

Discover some of the unique mechanisms Akkermansia employs to survive in the human gut and the genetics behind how this fascinating bacterium can maintain cholesterol homeostasis.
Read More