Prebiotic Supplements to Fight Inflammation

July 29, 2023 3 min read

Prebiotic Supplements to Fight Inflammation

Prebiotics are non-digestible dietary fibers that selectively stimulate the growth and activity of beneficial gut microorganisms. There is growing interest in the potential of prebiotic supplements to reduce inflammation, as inflammation has been linked to a wide range of chronic diseases. Here are five key points about prebiotic supplements and inflammation:

  • Prebiotic supplementation can lead to changes in the gut microbiota composition and activity, which may have anti-inflammatory effects. Some prebiotic fibers have been shown to increase the abundance of beneficial bacteria such as Bifidobacterium and Lactobacillus, which are known to have anti-inflammatory properties (1). In addition, prebiotics can promote the production of short-chain fatty acids (SCFAs) by gut bacteria, which have been shown to have anti-inflammatory effects (2).
  • Some prebiotic fibers, such as oligofructose-enriched inulin, have been shown to reduce inflammation markers such as C-reactive protein (CRP) in overweight and obese individuals. In one study, 44 overweight and obese adults consumed either 21 grams of oligofructose-enriched inulin or a placebo daily for 12 weeks. At the end of the study, the inulin group had significantly lower levels of CRP compared to the placebo group (3). Another study of 40 healthy adults found that a prebiotic mixture of galactooligosaccharides and fructooligosaccharides reduced levels of pro-inflammatory cytokines in the blood after three weeks of supplementation (4).
  • Prebiotics may have synergistic effects with probiotics and other dietary interventions in reducing inflammation and improving overall gut health. For example, a randomized controlled trial of 20 healthy adults found that a combination of prebiotics and probiotics improved gut microbiota diversity and reduced inflammation markers compared to a placebo (6). In addition, consuming a diet high in fruits, vegetables, and whole grains can provide a natural source of prebiotics and may have anti-inflammatory effects (7).
  • HMO prebiotic reduce inflammation through 3 ways: HMO prebiotics may prevent the growth of harmful bacteria in the gut which can trigger inflammation. By promoting the growth of beneficial bacteria, HMOs can help to maintain a healthy gut microbiota and reduce inflammation. Additionally, HMOs can act as a decoy for harmful bacteria, preventing them from binding to and invading the gut lining, which can also lead to inflammation. Secondly, HMOs may help to regulate the immune system. Studies have shown that HMOs can reduce the expression of inflammatory cytokines in immune cells and increase the expression of anti-inflammatory cytokines. This suggests that HMOs can help to balance the immune response and prevent excessive inflammation. Finally, HMOs may also have direct anti-inflammatory effects. Some studies have shown that HMOs can inhibit the production of pro-inflammatory molecules in immune cells, such as tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6).

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About Layer Origin: At Layer Origin, we are dedicated to unlocking the potential of Human Milk Oligosaccharides (HMOs). We believe that only God's gift could be so perfectly designed to support our gut health. Our goal is to make this super prebiotic available for both children and adults. Check out PureHMO and SuperHMO Prebiotics


  1. Roberfroid M, Gibson GR, Hoyles L, et al. Prebiotic effects: metabolic and health benefits. Br J Nutr. 2010;104 Suppl 2:S1-S63. doi: 10.1017/S0007114510003363
  2. den Besten G, van Eunen K, Groen AK, Venema K, Reijngoud DJ, Bakker BM. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res. 2013;54(9):2325-2340. doi: 10.1194/jlr.R036012
  3. Guess ND, Dornhorst A, Oliver N, Bell JD, Thomas EL, Frost GS. A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes. Nutr Metab (Lond). 2015;12:36. doi: 10.1186/s12986-015-0033-2
  4. Vulevic J, Juric A, Tzortzis G, et al. A mixture of trans-galactooligosaccharides reduces markers of metabolic syndrome and modulates the fecal microbiota and immune function of overweight adults. J Nutr. 2013;143(3):324-331. doi: 10.3945/jn.112.166132
  5. Cani PD, Neyrinck AM, Maton N, et al. Oligofructose promotes satiety in healthy human: a pilot study. Eur J Clin Nutr. 2005;59(3): 776-782. doi: 10.1038/sj.ejcn.1602129
  6. Plaza-Díaz J, Ruiz-Ojeda FJ, Vilchez-Padial LM, Gil A. Evidence of the anti-inflammatory effects of probiotics and prebiotics for intestinal microbiota modulation. Nutrients. 2017;9(6): 555. doi: 10.3390/nu9060555
  7. Giugliano D, Ceriello A, Esposito K. The effects of diet on inflammation: emphasis on the metabolic syndrome. J Am Coll Cardiol. 2006;48(4):677-685. doi: 10.1016/j.jacc.2006.03.052

1 Response

Amy Haas
Amy Haas

August 02, 2023

Specifically which product would you recommend for someone with sero positive rheumatoid arthritis, who is not overweight, and does not have constipation problems.? Thank you, Amy

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