MitiAging Anti-Aging Bundle

What is the MitiAging Bundle?

The MitiAging Bundle contains two products that work together to mitigate aging. Each bundle includes two bottles:

• Bottle 1 - Gut Biome Restore: Boost your gut with 5 HMO prebiotics and 10 probiotic strains, 30 day- supply.
• Bottle 2 -  Mitochondria Restore and Revive: 1000 mg of natural ellagic acid that’s converted into urolithin A in the gut, 30-day supply.  

 

How does the MitiAging Bundle work?

TheMitiAging Bundle targets the gut microbiome and its capacity to produce urolithin A, a compound bacteria produce when they break down certain foods. Urolithin A has been highlighted as having anti-aging effects, including:

• Improving cellular health
• Reducing inflammation
• Increasing mitochondrial function

The bundle contains two powerful products that work synergistically to help restore balance in your gut, promote the growth of Urolithin A-producing bacteria, and improve the gut's capability to produce urolithin A.

Does the MitiAging Bundle contain urolithin A?

No, unlike some urolithin A supplements which contain synthetic urolithin A, the  MitiAging Bundle doesn’t contain any urolithin A. Instead it works by enhancing your gut's ability to produce urolithin A naturally by supplementing the precursor, ellagic acid.

MitiAging Bundle vs Other Urolithin A Supplements

To understand the benefits of our MitiAging Bundle, we’ve provided a comparison table with some of the popular urolithin A supplement brands.

Unlike synthetic urolithin A supplements or other anti-aging products, the MitiAging Bundle works to restore balance within your gut microbiome, enabling it to regain ability to produce urolithin A naturally from dietary sources. Because the MitiAging Bundle helps to reset your gut, even if you stop taking the supplement, your gut should continue producing urolithin A, whereas, with synthetic supplements, their proposed anti-aging benefits stop once you stop taking them.

So, the MitiAging Bundle has several advantages over urolithin A supplements, not least because it restores the function of your gut microbiome which supports several other aspects of your health too.

Bottle 1: Gut Biome Restore

The Gut Biome Restore bottle contains 30 days’ worth of capsules that contain a patent-pending formula that seeds, diversifies and balances your gut microbiota.

A balanced microbiome is important for many aspects of your health, but a greater bacterial diversity in the gut has been shown to support urolithin A production.

As the following Figure shows, healthy gut microbiota produces high levels of Urolithin A from pomegranate ellagic acid. This percentage is significantly lower in cases of dysbiosis. HMO prebiotics and probiotics restore gut balance and boost the UA-producing microbes: Enterocloster citroniae and Gordonibacter (patent-pending).

Gut Biome Restore contains five different human milk oligosaccharides known to diversify, balance, and restore your gut microbiome. They are:

1. 2’-Fucosyllactose (2’FL) – The most abundant HMO in breast milk and has strong links to immunity, brain development, and combatting inflammation.
2. Lacto-N-neotetraose (LNnT) – A nitrogen-containing HMO that promotes the growth ofBifidobacteria,a probiotic that supports digestive health.
3. Lacto-N-tetraose (LNT) – An HMO known for its ability to modulate the immune system and has anti-inflammatory and antioxidant properties.
4. 3’-Sialyllactose (3’SL) – One of two sialylated HMOs that support brain, cardiovascular[ii], and bone health.
5. 6’-Sialyllactose (6’SL)– A sialylated HMO that may support brain development in infants and improve brain functions such as learning and memory in adults. Research also shows it may increase muscle mass and strength and increase endurance[iii].

These HMOs are naturally present in human breast milk and have been shown to modulate the composition and activity of the human gut microbiota and promote the growth of beneficial bacteria species, including Bifidobacteria.

Alongside the five HMOs, the Gut Biome Restore capsules also contain 10 probiotic bacteria strains to help diversify your microbiome with health-promoting bacterial strains.

Probiotics have several benefits for gut health, such as:

• Improving immunity
• Strengthening the gut mucosal lining
• Inhibiting the colonization of pathogenic bacteria
• Diversifying the natural ecosystem residing in the gut[iv]

Bottle 2: Mitochondrial Restore & Revive

The Mitochondrial Restore & Revive capsules deliver natural ellagic acid direct to your gut to nourish the bacteria and stimulate the production of urolithin A for enhanced mitochondrial health. The ellagic acid in the capsules is derived from pomegranates.

What is ellagic acid?

Ellagic acid is an antioxidant that’s naturally found in many foods, including pomegranates. Research shows that it has several health-promoting benefits including anti-cancer functions and antioxidant properties[v].

As an antioxidant, ellagic acid can neutralize free radicals, protecting your cells from damage and oxidative stress[vi]. It can also lower the number of inflammatory biomarkers in circulation such as interleukin-6 (IL-6) and prostaglandin E2[vii].

Ellagic acid → Urolithin A

Ellagic acid and urolithin A are intricately linked because of the gut microbiome. Because it is produced from the breakdown of certain ellagic acid-containing foods, urolithin A is a type of postbiotic. Here’s how ellagic acid and urolithin A are interlinked:

1. Ellagic is a precursor for urolithin A: Ellagic acid is a polyphenol that is not bioactive on its own but serves as a precursor for many bioactive anti-aging compounds, including the superstar molecule - urolithin A.
2. Certain gut bacteria metabolize ellagic acid into urolithins: Certain strains of bacteria, such asBifidobacteria longum,Bifidobacteria adolescentis,and Bifidobacteria bifidum, are critical for transforming ellagic acid into urolithin A[viii]. However, not everyone can efficiently produce urolithin A because it depends on the composition and functionality of your gut microbiome. Hence why it is important to restore balance in the gut to promote urolithin A production. 
3. Urolithin A’s bioactivity unleashes several health benefits:Once ellagic acid has been converted to urolithin A in the gut by specific bacterial strains it can have some significant health benefits, including:
   • Promotes autophagy: Stimulating the removal of damaged mitochondria to enhance energy production, and cellular efficiency, and prevent ongoing damage.
   • Anti-inflammatory properties: Urolithin A reduces inflammation, a major contributor to aging and chronic disease.
   • Anti-aging:Urolithin A can improve mitochondria health, help with mitophagy, muscle health, and endurance, particularly in aging populations, contributing to longevity[ix].  Want to know more about the 12 hallmarks of aging? Please read our blog.

How to take the MitiAging Bundle

The best way to take the MitiAging product is as follows:

The capsules can be taken with or without food, but they will be most effective if you incorporate at least 2 servings of fruit and vegetables into your diet per day.

The MitiAging Bundle can be taken to enhance your gut’s natural ability to produce urolithin A, but there are several things you can do to help support a balanced gut microbiome that’s essential for urolithin A production, such as:

• Eating a healthy, balanced diet that’s packed with natural foods such as fruits, vegetables, whole grains, and legumes to promote the growth and activity of beneficial bacteria. Try the gut farmer diet.
• Regular exercise increases the diversity of the gut microbiome and promotes the growth of beneficial species.
• Managing stress is important because it can alter the composition of the gut microbiome, significantly impacting its function. Try stress management techniques and activities like mindfulness, meditation, yoga, and breathing exercises.

Combining the  MitiAging Bundle with positive lifestyle choices can have a significant benefit for your gut and the bacteria residing in it.

Where can I buy the MitiAging Bundle?

If you’re keen to reset your gut microbiome and unlock it’s urolithin A-producing capabilities to help mitigate the signs of aging, then you need the MitiAging Bundle, which is available from our online shop.

Written by: Leanne Edermaniger, M.Sc. Leanne is a professional science writer who specializes in human health and enjoys writing about all things related to the gut microbiome.   

Sources

[i] Singh A, D'Amico D, Andreux PA, Dunngalvin G, Kern T, Blanco-Bose W, Auwerx J, Aebischer P, Rinsch C. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. Eur J Clin Nutr. 2022 Feb;76(2):297-308. doi: 10.1038/s41430-021-00950-1. Epub 2021 Jun 11. PMID: 34117375; PMCID: PMC8821002.

[ii] Pessentheiner AR, et al.. The human milk oligosaccharide 3'sialyllactose reduces low-grade inflammation and atherosclerosis development in mice. JCI Insight. 2024 Nov 8;9(21):e181329. doi: 10.1172/jci.insight.181329. PMID: 39325548; PMCID: PMC11601559.

[iii] Park EJ, Kim LL, Lee JO, Lee HY, Kim YA, Go HR. 6'-Sialyllactose Enhances Exercise Performance via Increased Muscle Mass and Strength. Nutrients. 2024 Aug 7;16(16):2600. doi: 10.3390/nu16162600. PMID: 39203737; PMCID: PMC11357526.

[iv] Wang X, Zhang P, Zhang X. Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity. Molecules. 2021 Oct 8;26(19):6076. doi: 10.3390/molecules26196076. PMID: 34641619; PMCID: PMC8512487.

[v] Derosa G, Maffioli P, Sahebkar A. Ellagic Acid and Its Role in Chronic Diseases. Adv Exp Med Biol. 2016;928:473-479. doi: 10.1007/978-3-319-41334-1_20. PMID: 27671829.

[vi] Ali SS, Ahsan H, Zia MK, Siddiqui T, Khan FH. Understanding oxidants and antioxidants: Classical team with new players. J Food Biochem. 2020 Mar;44(3):e13145. doi: 10.1111/jfbc.13145. Epub 2020 Jan 20. PMID: 31960481.

[vii] BenSaad LA, Kim KH, Quah CC, Kim WR, Shahimi M. Anti-inflammatory potential of ellagic acid, gallic acid and punicalagin A&B isolated from Punica granatum. BMC Complement Altern Med. 2017 Jan 14;17(1):47. doi: 10.1186/s12906-017-1555-0. PMID: 28088220; PMCID: PMC5237561.

[viii] He F, Bian Y, Zhao Y, Xia M, Liu S, Gui J, Hou X, Fang Y. In vitro conversion of ellagic acid to urolithin A by different gut microbiota of urolithin metabotype A. Appl Microbiol Biotechnol. 2024 Feb 16;108(1):215. doi: 10.1007/s00253-024-13061-1. PMID: 38363367; PMCID: PMC10873453.

[ix] Liu S, D’Amico D, Shankland E, Bhayana S, Garcia JM, Aebischer P, et al. Effect of urolithin a supplementation on muscle endurance and mitochondrial health in older adults. JAMA Network Open. 2022 Jan 20;5(1). doi:10.1001/jamanetworkopen.2021.44279