Can prebiotic supplements cause side effects?

July 25, 2023 2 min read

Can prebiotic supplements cause side effects?

While prebiotic supplements are generally safe and well-tolerated, they can cause side effects in some individuals, especially at higher doses. Common side effects include gastrointestinal symptoms such as bloating, gas, and abdominal discomfort. These symptoms are usually mild and temporary and can be managed by reducing the dose or discontinuing the supplement.

In rare cases, prebiotic supplements can cause more severe side effects, such as allergic reactions or worsening of pre-existing digestive conditions. Individuals with pre-existing medical conditions or taking medications should consult with their healthcare provider before taking prebiotic supplements.

For HMO prebiotics, it is not recommended for people with milk allergies since HMO contains trace amount of lactose (cow’s milk). However, people with lactose intolerance can still consume HMO because of the lactose content is very low in our HMO products.


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About Layer Origin: At Layer Origin, we are dedicated to unlocking the potential of Human Milk Oligosaccharides (HMOs). We believe that only God's gift could be so perfectly designed to support our gut health. Our goal is to make this super prebiotic available for both children and adults. Check out PureHMO and SuperHMO Prebiotics


  1. Gibson GR, Hutkins R, Sanders ME, et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017;14(8):491-502. doi:10.1038/nrgastro.2017.75
  2. Slavin J. Fiber and prebiotics: mechanisms and health benefits. Nutrients. 2013;5(4):1417-1435. doi:10.3390/nu5041417
  3. Roberfroid M, Gibson GR, Hoyles L, et al. Prebiotic effects: metabolic and health benefits. Br J Nutr. 2010;104 Suppl 2:S1-S63. doi:10.1017/S0007114510003363
  4. Saad MJ, Santos A, Prada PO. Linking gut microbiota and inflammation to obesity and insulin resistance. Physiology (Bethesda). 2016;31(4):283-293. doi:10.1152/physiol.00041.2015

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