PureHMO® IBS Support with IBS Defend Probiotic

  • Hits Root Cause of IBS: The imbalance of gut bacteria is one of the root causes of IBS. We focus on restoring the beneficial microflora and creating a positive environment for them to stay and thrive.  
  • Super Prebiotic HMOs: The unique blend of 2'-FL and  Lacto-n-neotetraose (LNnT) human milk oligosaccharides are clinically proven to relieve IBS symptoms, including constipation, gas, bloating, and diarrhea.
  • The IBS Defend Probiotic: The IBS defend Acidophilus probiotic strain was specially developed for IBS relief and was proven to reduce IBS discomfort in human trials.
  • Restore Gut Functions: The product is designed to restore the gut lining, strengthen gut barriers, build gut bacteria balance, and defend against bad bacteria and food intolerance. 


Restore Gut Microflora

Two kinds of HMOs: 2'-Fl and LNnT, to feed and restore bifidobacteria in the gut

Stool Consistency and Improved Regularity

Formulated with IBS Defend Lactobacillus acidophilus, a clinically-proven probiotic

Reduction of Abdominal Discomfort

Both HMOs and the probiotic were clinically proven to reduce abdominal discomfort (P<0.001, total~1000 participants)

Target the Root Cause of IBS

Gut microflora imbalance is one of the most important root causes of IBS. PureHMO® IBS Support is designed to restore gut flora and gut function.

How It Works

Experts' Opinions on HMO and IBS Defend Probiotic

expert opinion review stars

Dr. Olafur S. Palsson, Clinical and Translational Gastroenterology

"Daily oral administration of the 2 HMOs, 2'FL and LNnT in a 4:1 mix, for 12 weeks significantly improves bowel habits, other IBS symptoms, and health-related quality of life in adults who have clinical IBS diagnosis and fulfill the Rome IV criteria for IBS" (317 patients)

expert opinion review stars

Nutrients, Journal

"L. acidophilus and B. lactis UABla-12 improved abdominal pain and symptom severity scores with a corresponding normalization of bowel habits in adults with IBS." (Participants: 333 patients)

expert opinion review stars

Chr. Hansen / Health Canada

"Health Canada authorizes functional claim that “Lactobacillus Acidophilus helps improve abdominal pain severity and symptomology in Irritable Bowel Syndrome in adolescents and adults”

expert opinion review stars

AboutIBS. Org

"There is now evidence to support the idea that disturbances in the bacteria that populate the intestine may have a role in at least some people with irritable bowel syndrome (IBS)."


Gut microflora imbalance is one the most important root causes of IBS. Research indicates that the microflora in people with IBS differ from those in healthy people. Without good and balanced microflora, your digestive system will have difficulties fully digesting foods, which could trigger IBS.

The combination of two human milk oligosaccharides, 2'-FL and LNnT, feed good bacteria and enrich the biodiversity of gut microflora, especially those living on the gut lining. They are the key to normalizing the function of your gut.

You can simply mix the powder with water and take it right before meals. Please do not add the powder into hot beverages since this product also contains IBS Defend probiotic.

Menthol tends to solve the problem by suppressing bowel muscle spasms whereas PureHMO® IBS Support is designed to restore the gut flora and gut functions for a longterm fix.

Customer Reviews

Based on 19 reviews
V Riley
PureHMO® IBS Support with DDS-01 Probiotic

Helped me lose a few pounds! What a wonderful surprise!

James Friedrich
So Far So Good

I've been taking PureHMO for about a week now and starting to see a positive difference.

Marcia Beauchamp
Excellent product

PureHMO IBS Support has been a crucial factor in healing my leaky gut and I intend to keep these products in my ongoing nutritional tool box.

Denecka Henderson

I heard about this product on a podcast. I have tried all kinds of pro and pre biotics. My GI issues have never seem to improve. When I started HMO within the first week my bowel issues began to change for the better. I am on my second jar of HMO and keep seeing GI improvements week by week. Thank you Layer Origin for a quality product.

Solid product

Better for my IBS than the original without added IBS probiotics definitely. Relief within a day or two of starting