PureHMO® Human Milk Oligosaccharide (HMO 2'FL) Super Prebiotic Powder


Human Milk Oligosaccharide (HMO) is a super prebiotic found naturally in mother's milk. Today, fermented HMO provides all the benefits without containing any actual human milk. PureHMO® Prebiotic Powder feeds 200 Billion CFU Probiotics/Serving. 

  • Promote Healthy Gut Microflora: HMO prebiotic powder promotes the growth of probiotics like Bifidobacterium and Akkermansia Muciniphila.
  • Improve Immune System: HMO are more effective at enhancing innate immunity, blocking pathogens, and reducing inflammation than conventional prebiotics (GOS, XOS, Inulin FOS).
  • Support Cognitive Health: Unlike other probiotic and prebiotics for adults, HMO metabolites support brain development, neuronal transmission, and cognitive function.


        Super Prebiotic Fiber

        Feed Bifidobacteria and Akkermansia, increase beneficial bacteria in gut, build a healthy gut ecosystem.

        Cognitive Function

        The metabolites of HMO support brain development, neural transmission, cognitive functions, and motor skills

        Healthy Gut Microbiome

        Boost the number of probiotics in the gut; help with SIBO, food digestion, and weight management; build a solid foundation for long-term health.

        IBS Relief

        Clinically proven to reduce key symptoms of IBS such as gas, bloating, constipation, and stomach pain

        How It Works

        Experts' Opinion On HMO

        expert opinion review stars


        HMOs are helping to steer the but towards immunity and steering the macrophages towards restoration of the gut lining — I actually know a lot of functional medicine doctors using this with their patients now.

        Host, The Ben greenfield fitness podcast

        expert opinion review stars

        Dr. William Davis, MD

        HMOs also result in marked increases in intestinal butyrate that nourishes and heals the intestinal lining and yields metabolic benefits such as reduced blood sugar, reduced insulin resistance, reduced blood pressure, and improved mood, mental health, and sleep.

        Author of NY Times Best Seller, Wheat Belly

        expert opinion review stars

        DR. RHONDA PATRICK , Ph.D.

        These beneficial bacteria produce short-chain fatty acids that prevent colonization of pathogenic bacteria in the gut. This bacteria (good bacteria promoted by HMOs) has been shown to set up the immune system.


        expert opinion review stars


        They are food for developing gut microbiome. They are prebiotics and they actually help the right bacteria, specifically bifidobacteria, to grow. And this also helps with development of the immune system.



        Find the answer to commonly asked questions about PureHMO® Prebiotic Powder

        No. Our HMO is technically something referred to as HiMO, which stands for Human identical Milk Oligosaccharide. It is produced via a complex fermentation and precise purification process and results in a powder that is molecularly identical to the HMO that is in human milk. All the benefits without any human milk involved.

        Yes. Research has shown that many people with lactose intolerance can tolerate up to 12 grams of lactose in one sitting, which is approximately the amount in one cup (230 ml) of milk. Layer Origin Nutrition recommends a HMO serving size of 2.0 grams to start— therefore — even people with with lactose intolerance should be well below the limit of what they can tolerate, if they follow the recommended dosage.

        Believe it or not, it doesn't make a difference either way. This is because the HMO will not be digested the way that food would be digested. HMO makes its way undigested through your body down to the lower intestines, where it becomes the food for probiotic bacteria. So take HMO with food or without food. Either way is fine!

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        Customer Reviews

        Based on 159 reviews
        Dr. Stephen Stokes

        I have been experimenting with Layer Origins Pure HMO’s from April till Nov 2022, and I had completed 3 stool profile tests, one in June 2021 as a control (no HMO’s), one in July 2022 and one in November 2022. I have seen a dramatic increase in several health strains such as Prevotella spp., Bifidobacteria spp., Roseburia spp., Pichia spp., all which were almost non existent prior to the supplementation. I also have seen a major decrease in E.Coli. I started off with only taking 1 scoop of powder per day and I believe I would have done better, faster with 2 scoops a day. These are very impressive results, as someone who suffers from dysbiosis and associated anxiety I believe this product is the most important part of my treatment program. It takes time and you must also work on your diet, adding fiber and fermented foods which is difficult because until you have the right bacteria it will cause bloating and cramping but the HMO’s help and in the end restoring the colon’s diversity is the goal for complete recovery. Also I have tried other products that have HMO’s in them but find Pure HMO’s by Layer the best and easiest to consume. I will be a life time supporter and recommender of this product. I am in th eprocess of making a video of my entire experience and posting it on my website.

        Rich Maurer
        My bifido skyrocketed!

        My Bifidobacterium adolescentis went from .025% to 3.5% in les than 2 months!

        B. longum went from 1.6% to 2.6%.

        yozette collins
        Trustfall, baby

        I am trusting this works because the info I've read says it's beneficial! I love that it is flavorless and doesn't take a huge amount to reap benefits. Really like this and Layer Origin's mission in general.

        Gut health

        Using this and Apple peels and red phenols I have noticed a major change in my digestion. Significantly less gas and bloating and IBS issues.

        E. Davenport
        Quick and easy

        Dissolves instantly and completely. Tasteless to maybe faintly sweet. I’ve taken large doses without discomfort.