PureHMO® Human Milk Oligosaccharide (HMO 2'FL) Super Prebiotic Powder


Human milk oligosaccharide (HMO) is a super prebiotic occurring naturally in mother's milk. Today, fermented HMO delivers all the benefits without any actual human milk in the product. PureHMO® Prebiotic Powder feeds 200 Billion CFU Probiotics/Serving. 

  • Promote Healthy Gut Microflora: HMO prebiotic powder promotes the growth of probiotics like Bifidobacterium and Akkermansia Muciniphila.
  • Improve Immune System: HMO are more effective than traditional prebiotics (GOS, XOS, Inulin FOS) in stimulating innate immune system, blocking pathogens & reducing inflammation. 
  • Support Cognitive Health: Unlike other probiotic prebiotic for adults, HMO metabolites promote brain development, neuronal transmission, and cognition.


        Super Prebiotic Fiber

        Feed Bifidobacteria and Akkermansia, increase beneficial bacteria in gut, build a healthy gut ecosystem.

        Cognitive Function

        The metabolites of HMO support brain development, neural transmission, cognitive functions, and motor skills

        Healthy Gut Microbiome

        Boost the number of probiotics in the gut; help with SIBO, food digestion, and weight management; build a solid foundation for long-term health.

        IBS Relief

        Clinically proven to reduce key symptoms of IBS such as gas, bloating, constipation, and stomach pain

        How It Works

        Experts' Opinion On HMO

        expert opinion review stars


        HMOs are helping to steer the but towards immunity and steering the macrophages towards restoration of the gut lining — I actually know a lot of functional medicine doctors using this with their patients now.

        Host, The Ben greenfield fitness podcast

        expert opinion review stars


        What you're going to find with HMOs is that they are endemic to the formation of the immune system in the infant gut — and so HMOs have very, very strong presence informing immunity in the gut.

        Author, the immunity code

        expert opinion review stars

        DR. RHONDA PATRICK , Ph.D.

        These beneficial bacteria produce short-chain fatty acids that prevent colonization of pathogenic bacteria in the gut. This bacteria (good bacteria promoted by HMOs) has been shown to set up the immune system.


        expert opinion review stars


        They are food for developing gut microbiome. They are prebiotics and they actually help the right bacteria, specifically bifidobacteria, to grow. And this also helps with development of the immune system.


        HMOs Have Been Featured In:

        fobes logo
        the new york times logo
        nature logo
        bloomberg logo


        Find the answer to commonly asked questions about PureHMO® Prebiotic Powder

        No. Our HMO is technically something referred to as HiMO, which stands for Human identical Milk Oligosaccharide. It is produced via a complex fermentation and precise purification process and results in a powder that is molecularly identical to the HMO that is in human milk. All the benefits without any human milk involved.

        Yes. Research has shown that many people with lactose intolerance can tolerate up to 12 grams of lactose in one sitting, which is approximately the amount in one cup (230 ml) of milk. Layer Origin Nutrition recommends a HMO serving size of 2.0 grams to start— therefore — even people with with lactose intolerance should be well below the limit of what they can tolerate, if they follow the recommended dosage.

        Believe it or not, it doesn't make a difference either way. This is because the HMO will not be digested the way that food would be digested. HMO makes its way undigested through your body down to the lower intestines, where it becomes the food for probiotic bacteria. So take HMO with food or without food. Either way is fine!

        Customer Reviews

        Based on 90 reviews
        Great addition!

        I want to take this longer to really give my opinion, but so far I have noticed better digestion with certain foods. Excited to keep taking it.

        Keith Meador
        Good results

        I got good results after only a few days. Lessened bloating that had been an ongoing annoyance.

        Healing my gut

        I noticed a difference when I started taking this. I know my gut health is improving.


        My goodness, I’m delighted to have found this product and this company, and have been raving about it to family and friends. I have had, for the last couple years had terrible stomach pains/flatulence/food intolerance, which has been incapacitating. I had made my own kombucha, sauerkraut and kimchi, and I tried everything else I could get my hands on, like various commercial pre and probiotics, beano, lactaid, digestive bitters, Gas-x, Maalox, etc etc etc all to no avail. I was looking at maybe just eating cereal and plain toast the rest of my life because I could no longer digest all of my favorite foods (or any foods really). But when I read the research on the purehmo it made sense — the science behind it. I started it last Thursday. I do not wake up anymore with horrible stomach pains and gas in the morning!!! How amazing to find something to relieve my suffering. Thank you!!! And I especially love that you all utilize a 400 acre organic farm for growing and synthesizing ingredients. Consider me a devoted customer.

        Better digestion

        I don't know if it's the placebo effect or if it's for real - but in either case, it worked! =)