PureHMO® Human Milk Oligosaccharide Synbiotic - Prebiotic & Probiotic Combo

  • Prebiotic + Probiotic Combo: most other probiotic supplements contain just a small amount (<50 mg) of prebiotics. By comparison, our formula contains a potent 1000 mg of prebiotic (Human Milk Oligosaccharide) and 10 strains of probiotics, 40 Billion CFU. 
  • HMO Prebiotic: PureHMO® human milk oligosaccharide helps infants build a healthy digestive system from scratch. There is no better prebiotic than HMO to feed the probiotics and restore your gut.
  • Probiotic for Women and Men: PureHMO® Synbiotic is designed to restore the gut & immune system, relieve IBS & constipation, suppress SIBO, achieve healthy weight loss, and improve mental & overall health


Synbiotic: HMO Prebiotic + HMO Probiotics

Each serving provides 1000 mg of HMO and billions of bifidobacteria that feed on HMO

Regain Gut Balance

HMO feeds the bifidobacteria in your gut, where the metabolites of those bacteria feed other probiotic bacteria and restore gut balance

Promote Gut Diversity

10 strains: Bifidobacterium bifidum, Bifidobacterium lactis, Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus gasseri, Lactobacillus paracasei, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus

Stronger Gut Functions

HMO super prebiotics feed Akkermansia and strengthen gut barriers

How It Works

expert opinion review stars

Nutrition Insight

"2’-FL is the most abundant HMO in many mothers and selectively promotes the growth of bifidobacterial strains, while generally known prebiotics promote bacterial growth on a broader level. Bifidobacteria are recognized as beneficial bacteria not only during infancy, but throughout human life. They are protective by lowering inflammation, enhancing gut barrier function and providing fuel for intestinal cells via generating short chain fatty acids"

expert opinion review stars

Dr. William Davis, MD

"HMOs also result in marked increases in intestinal butyrate that nourishes and heals the intestinal lining and yields metabolic benefits such as reduced blood sugar, reduced insulin resistance, reduced blood pressure, and improved mood, mental health, and sleep."

expert opinion review stars

Integrative Medicine, Book

"Synbiotics are a combination of prebiotics and probiotics that are believed to have a synergistic effect by inhibiting the growth of pathogenic bacteria and enhancing the growth of beneficial organisms"

expert opinion review stars

Critical Reviews in Food Science and Nutrition

"HMOs are not digested but are selectively utilized by certain beneficial gut bacteria, such as Bifidobacterium longum subsp. infantis (B. infantis) and Bifidobacterium bifidum. In addition to this prebiotic function, HMOs can hinder the adhesion of pathogens to gut epithelial cells, directly affect the maturation and development of gut epithelial cells, and support immune functions"


Bifidobacteria: 10 Billion CFU/Serving
Lactobacillus: 30 Billion CFU/Serving
Total Probiotics: 40 Billion CFU/Serving

No, it is shelf-stable at room temperature. However, you can choose to keep it in your refrigerator for a longer shelf-life.

Yes, you can use it with PureHMO® super prebiotic powder, PureHMO® super prebiotic capsules, or PureHMO® Tri-Prebiotic.

Customer Reviews

Based on 27 reviews
Teresa C
Amazing product!

I love ALL of the layer origin products! I use this everyday. I literally can’t live without these products now. They made such a significant impact in my life. I feel better then ever I ditched every other supplement I ever used and only use layer origins now!

Marilyn Ferraro
Top of the line!

This is the best probiotic/prebiotic I have ever tried. My digestive issues are history since I started using it and I highly recommend it.

Gabby I
Best probiotic I've tried

I've tried a lot of different probiotics for my gut health, some more helpful than others. This one is miles above any other one in how quickly and noticeably it improved my health. I still have issues sometimes which can't be helped since there are a lot of other factors like stress at play, but this product is fantastic. I order it internationally because nothing I've found locally was as helpful. The combination of probiotics and HMOs seems to be really beneficial for me compared to any other regular probiotic.

game changer

will not be without this supplement now. really relieves GI pain and pressure.

Dr Christine Bishara
Easy to add to your daily regimen

I received this to try and so far I like it. Been giving to my kids too. Has a nice combo of beneficial microbes.